Laboratory of Infection Biology

Laboratory of Infection Biology

JIVAN (Jiva-Vijnan-Anweshan-Niketan) — Centre for Research in Biological Sciences, RKMVERI


Arnab Basu
Assistant Professor & Ramalingaswami Fellow
JIVAN Research Centre,
Department of Biomedical Science and Technology
School of Biological Sciences, RKMVERI
RKMSP Hospital, 99, Sarat Bose Road, Kolkata-700026
West Bengal, India

Research Interests

  1. Regulation of bacterial growth and pathogenesis
  2. Genetic analysis of antibiotic resistance
  3. Nanomedicine as modern therapeutics

Ongoing projects

  1. Role of TRAFAC GTPase in cellular physiology and stress response of Staphylococcus aureus
  2. Deciphering the importance of ABCF ATPase in antibiotic resistance.
  3. Effect of nanomedicine on bacterial pathogen
  4. Genetic analysis of pathogen associated with hospital based infection.
  5. Effect of metal ion on the growth and pathogenesis of bacteria.

Recent Publications

  1. Chakraborty A., Halder S., Kishore P., Saha D., Saha S., Sikder K., Basu A.*; 2022, The structure-function analysis of Obg like GTPase proteins along the evolutionary tree from bacteria to humans, Genes to Cells. 2022, 27(7) 469-481* Corresponding author
  2. Roy S. M., Barman S., Basu A., Ghatak T., Pore S. K., Ghosh S. K., Mukherjee R., Maity A. R., Amine as a bottom-line functionality on DDS surface for efficient endosomal escape and further subcellular targets. Journal of Drug Delivery Science and Technology, 2022, 71(2003)103303.
  3. Basu A., Shields K. & Yap M.N.F. Hibernating 100S complex is a target of ribosome recycling factor and elongation factor G in Staphylococcus aureus. Journal of Biological Chemistry. 2020; 295(18): 6053–6063
  4. Basu A., Shields K., Eickhoff S.C., Hoft F.D & Yap M.N.F. Thermal and nutritional regulation of ribosome hibernation in Staphylococcus aureus. Journal of Bacteriology. 2018; 200(24):418-426
  5. Basu A. & Yap M.N.F. Disassembly of the Staphylococcus aureus hibernating 100S ribosome by an evolutionary conserved GTPase. Proceedings of the National Academy of Sciences USA. 2017; 114(39): 8165-8173
  6. Matzov D., Aibara S., Basu A., Zimmerman E., Bashan A, Yap M.N.F., Amunts A. & Yonath A. The Cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus. Nature Communications. 2017; 8(1):723-733
  7. Basu A. & Yap M.N.F. Ribosome hibernation factor promotes Staphylococcal survival and differentially represses translation. Nucleic Acid Research. 2016; 44(10):4881-4893

Selected scientific achievements

  • Recipient of DBT Ramalingaswami Re-entry Fellowship
  • Associate Editor of Frontiers in Bioengineering and Biotechnology