Laboratory of Infection Biology

Laboratory of Infection Biology

JIVAN (Jiva-Vijnan-Anweshan-Niketan) — Centre for Research in Biological Sciences, RKMVERI

 

Arnab Basu
Assistant Professor & Ramalingaswami Fellow
JIVAN Research Centre,
Department of Biomedical Science and Technology
School of Biological Sciences, RKMVERI
RKMSP Hospital, 99, Sarat Bose Road, Kolkata-700026
West Bengal, India
Contact:
Email:

Research Interests

  1. Regulation of bacterial growth and pathogenesis
  2. Genetic analysis of antibiotic resistance
  3. Nanomedicine as modern therapeutics

Ongoing projects

  1. Role of TRAFAC GTPase in cellular physiology and stress response of Staphylococcus aureus
  2. Deciphering the importance of ABCF ATPase in antibiotic resistance.
  3. Effect of nanomedicine on bacterial pathogen
  4. Genetic analysis of pathogen associated with hospital based infection.
  5. Effect of metal ion on the growth and pathogenesis of bacteria.

Recent Publications

  1. Saha S, RoyChowdhury D, Khan AH, Mandal S, Sikder K, Manna D, Maity AR, Chakraborti S, Basu A*. Harnessing the effect of iron deprivation to attenuate the growth of opportunistic pathogen Acinetobacter baumannii. Antimicrob Agents Chemother. 2025 Apr 9:e0168924. doi: 10.1128/aac.01689-24. Epub ahead of print. PMID: 40202344.* Corresponding author
  2. Chakraborty A., Bhakta K., Ghosh A., Manna D., Maity A. R., Sikder K., Chakraborti S.*, Basu A.*, 2025, Artesunate perturbs GTP binding of the conserved GTPase Obg thereby alleviating antibiotic resistance in methicillin-resistant Staphylococcus aureus. ACS Infect. Dis. (Just accepted) * Corresponding author
  3. Barman S, Roy SM, Kishore P, Ghosh M, Bag P, Sarkar AK, Ghatak T, Maji PS, Basu A, Mukherjee R, Ghosh SK, Chowdhury AD, Maity AR. Concurrent targeted delivery of doxorubicin and curcumin to the cancer cells using simple and versatile ligand-installed multifaceted chitosan-based nanoconjugates. J Mater Chem B. 2025 Feb 12;13(7):2490-2503. doi: 10.1039/d4tb01809e. PMID: 39834258.
  4. Saha S., Kar R., Kunal Sikder K., Manna D., Pal R.R., Chakraborti S, Khan A.H., Barman S., Maity A.R.*, Basu A.*, 2024, Deciphering the inhibitory mechanism of antimicrobial peptide pexiganan conjugated with sodium-alginate chitosan-cholesterol nanoparticle against the opportunistic pathogen Acinetobacter baumannii. J. Drug Deliv. Technol., 71(2003)103303. 101 (2024) 106305 * Corresponding author
  5. Dinda SK, Hazra S, De A, Datta A, Das L, Pattanayak S, Kumar K, Dey MD, Basu A, Manna D. Amoebae: beyond pathogens- exploring their benefits and future potential. Front Cell Infect Microbiol. 2024 Dec 18;14:1518925. doi: 10.3389/fcimb.2024.1518925. PMID: 39744153; PMCID: PMC11688213.
  6. Talukdar D, Haldar AK, Kumar S, Dastidar R, Basu A, Roy A, Sarkar S, Dey S, Sikder K. Leukocyte infiltration and cross-talk with cardiomyocytes exploit intracellular stress pathways in dilated cardiomyopathy of idiopathic origin. Mol Biol Rep. 2024 Oct 24;51(1):1090. doi: 10.1007/s11033-024-10028-3. PMID: 39446238.
  7. Saha C, Saha S, Chakraborty A., Dirisala A., Maity A R, Bhowmik P, Sikder K, Chakraborty S, Basu A. * 2023, Deciphering the structural and functional properties of ABCF ATPase. Infect Dis Diag Treat 7: 225. https://doi.org/10.29011/2577-1515.100225 * Corresponding author
  8. Modi B, Bahadur S, Bhowmik P, Chakraborti S, Dirisala A, , Khan A H, Ghosh A, Mondal S, Maity A R, Basu A.*; Curcumin and Colistin are Synergistic in Inhibiting the Growth and Biofilm Formation of Pseudomonas aeruginosa Isolated from Environmental Sample. Infect Dis Diag Treat,7(2), DOI: 10.29011/2577-1515.100218 * Corresponding author
  9. Roy S.M., Barman S., Kishore P., Bag P., Ghatak T., Basu A., Dirisala A. , Sarkar A. K., Ali H.K., Maity A.R. *, 2023, Acidic pH-Triggered Release of Doxorubicin from Ligand-Decorated Polymeric Micelles Potentiates Efficacy against Cancer Cells. ACS Appl. Nano Mater., 6(20), 18988–18998 ISSN 2574-0970
  10. Barman B, Chakraborty A, Saha S, Sikder K, Roy S M, Modi B, Bahadur S, Khan A H, Manna D, Bag P, Sarkar A, Bhattacharya R, Maity A R*, Basu A* 2023, Efficient Synergistic Antibacterial Activity of α-MSH Using Chitosan-Based Versatile Nanoconjugates, ACS Omega, 8(14):12865–12877 * Corresponding author
  11. Chakraborty A., Halder S., Kishore P., Saha D., Saha S., Sikder K., Basu A.*; 2022, The structure-function analysis of Obg like GTPase proteins along the evolutionary tree from bacteria to humans, Genes to Cells. 2022, 27(7) 469-481* Corresponding author
  12. Roy S. M., Barman S., Basu A., Ghatak T., Pore S. K., Ghosh S. K., Mukherjee R., Maity A. R., Amine as a bottom-line functionality on DDS surface for efficient endosomal escape and further subcellular targets. Journal of Drug Delivery Science and Technology, 2022, 71(2003)103303.
  13. Basu A., Shields K. & Yap M.N.F. Hibernating 100S complex is a target of ribosome recycling factor and elongation factor G in Staphylococcus aureus. Journal of Biological Chemistry. 2020; 295(18): 6053–6063
  14. Basu A., Shields K., Eickhoff S.C., Hoft F.D & Yap M.N.F. Thermal and nutritional regulation of ribosome hibernation in Staphylococcus aureus. Journal of Bacteriology. 2018; 200(24):418-426
  15. Basu A. & Yap M.N.F. Disassembly of the Staphylococcus aureus hibernating 100S ribosome by an evolutionary conserved GTPase. Proceedings of the National Academy of Sciences USA. 2017; 114(39): 8165-8173
  16. Matzov D., Aibara S., Basu A., Zimmerman E., Bashan A, Yap M.N.F., Amunts A. & Yonath A. The Cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus. Nature Communications. 2017; 8(1):723-733
  17. Basu A. & Yap M.N.F. Ribosome hibernation factor promotes Staphylococcal survival and differentially represses translation. Nucleic Acid Research. 2016; 44(10):4881-4893

Selected scientific achievements

  • Recipient of DBT Ramalingaswami Re-entry Fellowship
  • Associate Editor of Frontiers in Bioengineering and Biotechnology