Brahmachari Vedeshachaitanya (Somnath Maharaj)

Brahmachari Vedeshachaitanya (Somnath Maharaj)

Area of Research:

  • Understanding the mechanism of drug resistance in cancer, specially in Multiple Myeloma, one of the most common forms of Blood cancer.
  • Role of non-coding RNAs in the development of Cancer.

Contact address

91-33-2654-9999, ,

Education 

  • Ph.D. (Biotechnology), 2022.
  • M.Sc. (Biophysics), 2018.

Previously

Tata Institute of Fundamental Research (TIFR), Mumbai

Publications

Publications under the name Brahamachari Vedeshachaitanya Somnath

  1. Bhattacharyya, S., Chaudhury, D., Vedeshachaitanya, B., & Malakar, P. (2026). Long noncoding RNAs in insulin signaling: mechanisms, metabolic roles, and therapeutic prospects. Diabetes Research and Clinical Practice, 113320. https://doi.org/10.1016/j.diabres.2026.113320.
  2. Bhattacharyya, S., Choudhury, D., Vedeshachaitanya, B., & Malakar, P. (2026) Polyploidy and senescence of cancer cells – impact of cell fusion. In: Cell Fusion. Chapter 10. https://doi.org/10.1007/978-3-032-22637-2.
  3. Singha, D., Choudhury, D., Mondal, M., Hossain, J., Vedeshachaitanya, B., & Malakar, P. Downregulation of mTORC1 signaling is associated with increased sensitivity to protein synthesis perturbations in multiple myeloma. (Under Review)
  4. Hossain, J., Choudhury, D., Bhattacharyya, S., Vedeshachaitanya, B., & Malakar, P. Molecular determinants of bortezomib sensitivity and resistance in multiple myeloma: An integrated review. (Under Review)
  5. Hossain, J., Choudhury, D., Bhattacharya, S., Vedeshachaitanya, B., & Malakar, P. Ras signaling in cancer: From molecular mechanisms to next-generation therapeutic inhibitors. (Under Review)

Publications under Pre-monastic name

  1. Somnath Ghosal and Subrata Banerjee. In silico bioinformatics analysis for identification of differentially expressed genes and therapeutic drug molecules in Glucocorticoid-resistant Multiple myeloma. Medical Oncology, 2022;39(5):53. https://doi.org/10.1007/s12032-022-01651-w.
  2. Somnath Ghosal and Subrata Banerjee. Investigating the potential molecular players and therapeutic drug molecules in Carfilzomib resistant Multiple myeloma by comprehensive bioinformatics analysis. Leukemia & Lymphoma, 2022;1-12. https://doi.org/10.1080/10428194.2022.2087064.
  3. Somnath Ghosal, Saran Chattopadhyaya and Subrata Banerjee. In silico and in vitro analysis of differentially expressed micro RNAs, circular RNAs and p53 in Bortezomib resistant Multiple myeloma. Biomedical Research and Therapy, 2022; 9(7), 5179- 5190. https://doi.org/10.15419/bmrat.v9i7.754.
  4. Somnath Ghosal and Subrata Banerjee. Identification of potential molecular players and therapeutic drug molecules in Melphalan resistant Multiple myeloma by integrated bioinformatics analysis. Research Journal of Biotechnology, 17(12):6-15. https://doi.org/10.25303/1712rjbt06015.
  5. Saran Chattopadhyaya* and Somnath Ghosal*. DNA methylation: a saga of genome maintenance in hematological perspective. Human Cell, 2022;35(2):448-461. (*Equal Contribution). https://doi.org/10.1007/s13577-022-00674-9.
  6. Somnath Ghosal and Subrata Banerjee. Identification of Differentially Expressed Genes and Therapeutic Drug Molecules in Glucocorticoid Resistant Multiple Myeloma by In Silico Bioinformatics Analysis. Indian Journal of Hematology and Blood Transfusion, 2021;37(Suppl 1):1-172. https://doi.org/10.1007/s12288-021-01510-0.

Research Interests

Multiple Myeloma, miRNA-Circular RNA, DNA methylation, Drug resistance in myeloma, Bioinformatics.

Ongoing Research Project

Project No. Funding Agency Title of the project and duration (Start and end date)
ANRF/ARG/2025/007168/LS Anusandhan National Research Foundation (ANRF), Department of Science and Technology, Government of India. Understanding the Mechanisms of Chemoresistance to Bortezomib in Multiple Myeloma and Exploring Therapeutic Strategies to Enhance Drug Sensitivity. 2026-2029 (3 years)